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  • Worldwide, female breast cancer has now surpassed lung cancer as the most commonly diagnosed cancer.

  • An estimated 2,261,419 new cases were diagnosed in women across the world in 2020.

  • The breast cancer disease accounts for 1 in 3 of new female cancers annually.

  • Worldwide, female breast cancer is the fifth leading cause of death.

  • In 2020, an estimated 684,996 women across the world died from breast cancer.

Breast Cancer Clinical Treatment Methods
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    evidence after long-term application

Tamoxifen (Nolvadex)

Introduction of Drug Information

【Product Name】 Nolvadex
【General Name】 Tamoxifen
【Specification】 20mg/30 tables
【Manufacturer】 AstraZeneca
【Pharmacological Effects】 Tamoxifen is a nonsteroidal antiestrogen drug. Its structure is similar to that of estrogen, and there are two isomers, Z-type and E-type. The two have different physical and chemical properties and different physiological activities. E-type has weak estrogenic activity, while Z-type has anti-estrogenic effect. If breast cancer cells have estrogen receptor (ER), estrogen enters into tumor cells, binds to it, promotes the synthesis of DNA and m-RNA of tumor cells, and stimulates tumor cell growth. The Z-isomer of tamoxifen enters into cells, competes with ER for binding, forms receptor complexes, prevents the exertion of estrogen, thereby inhibiting the proliferation of breast cancer cells.
【Indications】 Tamoxifen (Nolvadex) is indicated for the treatment of advanced breast and ovarian cancer.
【Dosage and Administration】 Oral: 10-20 mg each time, 2 times a day, can be used continuously. Or as directed by a doctor.
【Adverse Reactions】 1. Adverse reactions include nausea, vomiting, diarrhea, menstrual disorders, vaginal bleeding, facial flushing, hair loss, rash, headache, dizziness, weight gain, edema, bone pain, tumor pain. Long-term heavy use can cause visual impairment, and occasional leukocyte and thrombocytopenia.
2. It has an effect on the fetus and is contraindicated in pregnant women.
3. Patients with abnormal blood picture and liver and kidney function should be used with caution.
4. Occasional perineal itching, increased leucorrhea.
5. Sometimes it can cause hypercalcemia, which occurs within 1 to 2 weeks.
【Precautions】 Patients with abnormal liver function should be used with caution. If there is bone metastases, blood calcium should be checked regularly at the beginning of treatment.
【Pregnant and Lactating Women Medication】 Have an effect on the fetus, pregnant and lactating women are prohibited.
【Drug Interactions】 Estrogen can affect the therapeutic effect of this product; antacids, cimetidine, ranitidine, etc. change the pH value in the stomach, make the casing of this product decompose in advance, and have a stimulating effect on the stomach.
Tamoxifen (Nolvadex) FAQs
  • 疑问一

    Is Tamoxifen (Nolvadex) a hormonal drug?

  • Tamoxifen (Nolvadex) is a non-steroidal anti-estrogen drug, not a hormone drug, but an anti-estrogen drug.

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  • 疑问二

    Does Tamoxifen (Nolvadex) have to be taken for 5 years?

  • Tamoxifen (Nolvadex) is a prescription drug, mainly used for the treatment of advanced breast cancer and ovarian cancer. Whether it needs to be used for 5 years, the patient needs to be reviewed regularly, and the attending doctor will evaluate whether it can continue to be taken according to the patient's disease condition. Under normal circumstances, doctors will advise patients with better control to stick to Tamoxifen (Nolvadex), and some patients may take the drug for more than 5 years. Because each person's drug absorption and disease control will have certain individual differences, please follow the doctor's advice for the specific drug duration.

    药 师

  • 疑问三

    Can Tamoxifen (Nolvadex) be used by men?

  • Tamoxifen (Nolvadex) is a clinical drug that can also be taken by men.

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  • 疑问四

    Tamoxifen (Nolvadex) has many side effects and needs to be stopped?

  • If there are many side effects of Tamoxifen (Nolvadex), please ask the patient's attending doctor in detail. The doctor depends on the severity of the patient's adverse reactions to determine whether to continue taking Tamoxifen (Nolvadex) or switch to other drugs.

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  • 疑问五

    What are the consequences of an overdose of Tamoxifen (Nolvadex)?

  • Tamoxifen (Nolvadex) is a non-steroidal anti-estrogen drug. Its dosage is usually determined by scientific calculation. Please strictly follow the doctor's prescribed dosage. It is not recommended to increase the dosage without authorization to avoid greater adverse reactions.

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