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Lomustine (Gleostine, Ceenu) Product Information
Lomustine alkylates DNA and RNA. Lomustine (Gleostine, Ceenu) is an alkylating drug indicated for the treatment of patients with:
Brain tumors, primary and metastatic, following appropriate surgical and/or radiotherapeutic procedures.
Hodgkin's lymphoma in combination with other chemotherapies, following disease progression with initial chemotherapy.
Lomustine (Gleostine, Ceenu)
Lomustine (Gleostine, Ceenu)

Introduction of Drug Information

【Product Name】 Gleostine
【General Name】 Lomustine
【Alias】 Ceenu
【Manufacturer】 Bristol-Myers Squibb
【Specification】 Capsule: 10mg*20 capsules; 40mg*20 capsules; 100mg*20 capsules
【Storage】 Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Avoid temperatures over 40°C (104°F).
【Indications】 In addition to its proven use as a single-agent therapy, CeeNU can also be used to establish combination therapy with other approved chemotherapeutics in:
Brain tumors, primary and metastatic, following appropriate surgical and/or radiotherapeutic procedures.
Hodgkin's lymphoma in combination with other chemotherapies, following disease progression with initial chemotherapy.
【Mechanism of Action】 Lomustine (Gleostine, Ceenu) alkylates DNA and RNA. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.
【Adverse Reactions】 Nausea and vomiting can occur within 6 hours after oral administration, which can last for 2 to 3 days, and can be alleviated by pre-sedation or metoclopramide and taking the drug on an empty stomach; a few patients have gastrointestinal bleeding and liver function damage.
Bone marrow suppression, thrombocytopenia can be seen 3 to 5 weeks after taking the drug, and leukopenia can appear twice in the 1st and 4th weeks after taking the drug, and only recovers in the 6th to 8th week; however, myelosuppression is cumulative.
Occasionally a generalized rash may be teratogenic, and it may also inhibit testicular or ovarian function, causing amenorrhea or lack of sperm.
【Overdosage】 Accidental overdose of lomustine, including fatal cases, have been reported. Accidental overdose has been associated with bone marrow suppression, abdominal pain, diarrhea, vomiting, anorexia, lethargy, dizziness, abnormal liver function, cough, shortness of breath.
There is currently no established effective antidote for Lomustine (Gleostine, Ceenu) overdose. In case of overdose, appropriate supportive measures should be taken.
【Precautions】 (1) Pregnant women and lactating women should be banned from using it because it can cause mutations and aberrations;
(2) Interference with diagnosis: This product can cause temporary abnormality of liver function;
(3) Use with caution in the following situations: myelosuppression, infection, renal insufficiency, patients treated with radiation therapy or anticancer drugs, or patients with a history of leukopenia;
(4) During the treatment period, attention should be paid to follow-up examination of blood routine and platelets, blood urea nitrogen, blood uric acid, creatinine clearance rate, blood bilirubin, alanine aminotransferase, etc;
(5) Patients should be taken together with antiemetics and sleeping pills before going to bed, and they should not drink alcohol on the day of medication;
(6) Pulmonary function should be checked before and during treatment.
Dosage and Administration
The recommended dose of Lomustine (Gleostine, Ceenu) in adult and pediatric patients is 130 mg/m 2 taken as a single oral dose every 6 weeks. Round doses to the nearest 10 mg. Give as a single oral dose and do not repeat for at least 6 weeks. Reduce dose to 100 mg/m 2 every 6 weeks in patients with compromised bone marrow function. Also reduce dose accordingly when using with other myelosuppressive drugs.
Doses after the initial dose should be adjusted based on the patient's hematologic response to the previous dose. Modify each dose of Lomustine (Gleostine, Ceenu) according to the hematologic response of the preceding dose as described:
Nadir After Prior Dose Dose Adjustment
Leukocytes (/mm)³) Platelets (/mm)³)
≥4000 ≥10000 100%
3000-3999 75,000-99,999 100%
2000-2999 25,000-74,999 70%
<2000 <25,000 50%
Where can I buy Lomustine (Gleostine, Ceenu)?
Patients can learn about the Lomustine (Gleostine, Ceenu) directly mailed by the pharmaceutical factory through Hong Kong Magicure, which can be mailed directly to their home to ensure that the drug is genuine, and the price is affordable and cost-effective. Hong Kong Magicure has cooperated with many medical institutions and patients and is deeply trusted. If necessary, welcome to inquiry, email: hkmagicure@gmail.com.

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