|Capsule: 10mg*20 capsules; 40mg*20 capsules; 100mg*20 capsules
|Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Avoid temperatures over 40°C (104°F).
|In addition to its proven use as a single-agent therapy, CeeNU can also be used to establish combination therapy with other approved chemotherapeutics in:
Brain tumors, primary and metastatic, following appropriate surgical and/or radiotherapeutic procedures.
Hodgkin's lymphoma in combination with other chemotherapies, following disease progression with initial chemotherapy.
|【Mechanism of Action】
|Lomustine (Gleostine, Ceenu) alkylates DNA and RNA. As with other nitrosoureas, it may also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins.
|Nausea and vomiting can occur within 6 hours after oral administration, which can last for 2 to 3 days, and can be alleviated by pre-sedation or metoclopramide and taking the drug on an empty stomach; a few patients have gastrointestinal bleeding and liver function damage.
Bone marrow suppression, thrombocytopenia can be seen 3 to 5 weeks after taking the drug, and leukopenia can appear twice in the 1st and 4th weeks after taking the drug, and only recovers in the 6th to 8th week; however, myelosuppression is cumulative.
Occasionally a generalized rash may be teratogenic, and it may also inhibit testicular or ovarian function, causing amenorrhea or lack of sperm.
|Accidental overdose of lomustine, including fatal cases, have been reported. Accidental overdose has been associated with bone marrow suppression, abdominal pain, diarrhea, vomiting, anorexia, lethargy, dizziness, abnormal liver function, cough, shortness of breath.
There is currently no established effective antidote for Lomustine (Gleostine, Ceenu) overdose. In case of overdose, appropriate supportive measures should be taken.
|(1) Pregnant women and lactating women should be banned from using it because it can cause mutations and aberrations;
(2) Interference with diagnosis: This product can cause temporary abnormality of liver function;
(3) Use with caution in the following situations: myelosuppression, infection, renal insufficiency, patients treated with radiation therapy or anticancer drugs, or patients with a history of leukopenia;
(4) During the treatment period, attention should be paid to follow-up examination of blood routine and platelets, blood urea nitrogen, blood uric acid, creatinine clearance rate, blood bilirubin, alanine aminotransferase, etc;
(5) Patients should be taken together with antiemetics and sleeping pills before going to bed, and they should not drink alcohol on the day of medication;
(6) Pulmonary function should be checked before and during treatment.
There are many risks in purchasing drugs through various information channels on the Internet:
Hong Kong Magicure Medical Co., Ltd. adheres to the business philosophy of "focusing on oncology medication and continuously improving patients' health", cooperate sincerely with the majority of upstream suppliers, and strive to provide hospitals, pharmacies and their patients with more professional, reliable and assured pharmaceutical products and services in the field of drug use for major chronic diseases. Help more patients relieve pain, regain health, and create a better future.